CerebralIschemia相关论文
脑缺血(cerebral ischemia,CI)具有高发病率、高致畸率,是全球第二大致死疾病.中药(traditional Chinese medicine,TCM)益气活血方......
Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and......
Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals an......
Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippo
Electroacupuncture (EA) has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipem......
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Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model
Leukemia inhibitory factor (LIF) contributes to the neuroprotection by neural stem cells (NSCs) after ischemic stroke.Ou......
The preliminary study on middle cerebral artery occlusion induced hyperacute infarction of rabbit br
Objective To investigate the diagnostic efficacy of magnetic resonance diffusion-weighted imaging ( DWI ) on acute middl......
MicroRNA-99a(miR-99a) has been reported to function as a tumor suppressor through regulating cell cycle and apoptosis.Bu......
Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte mig
Objective The formation of glial scar impedes the neurogenesis and neural functional recovery following cerebral ischemi......
Preconditioning with recombinant HMGB1 induces ischemic tolerance in a rat model of focal cerebral i
Preconditioning means that a previous minor insult prepares the body to better withstand a subsequent larger insult.High......
Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen spec
Background and Purpose We aimed to investigate whether NADPH oxidase,a major ROS-producing enzyme,was involved in the an......
Adenosine A2b receptor agonist inhibits tPA-induced hemorrhagic transformation after cerebral ischem
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Electro-acupuncture increases the proliferation of neural progenitor cells in the cortical peri-infa
Objective: Electro-acupuncture(EA)is a novel therapy based on combining traditional acupuncture with modern electrothera......
Sphingosine kinases(Sphks) are the rate-limiting kinases in the generation ofsphingosine-1-phosphate,which is a well-est......
Protective effect of celastrol in rat cerebral ischemia model:Down-regulating p-JNK,p-c-Jun and NF-κ
Background:Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may rep......
Effects of potassium channel on neuronal apoptosis induced by oxygen-glucose deprivation with or wit
Aim: It was generally believed that excessive potassium efflux was one of the primary causes of neuronal injury after ce......
Cerebroprotection by hesperetin is associated with restoration of tryptophan metabolic enzyme system
Aim: The tryptophan metabolic enzyme systems of indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase (TrpR......
Up-regulation of astroglial lipid-sensitive two-pore domain potassium channel TREK-1 in rat CNS afte
The lipid-sensitive mechano-gated TREK-1 has been shown to be predominantly expressed in the CNS.However, its regional a......
Objective For investigating whether overexpression of PDZ1 domain of PSD-95 can inhibit apoptosis in neurons induced by ......
Unilateral cerebral ischemia differentially damages cortical projection neurons and causes ipsilater
Objective Decreased blood flow to the brain causes stroke and damage to neuronal networks.Neuronal damage occurs not onl......
Background Various mammalian species,including human being,have neural stem cells (NSCs) in central nervous system all t......
Introduction:Transient receptor potential vanilloid 4 (TRPV4) is widely expressed in the central nervous system and can ......
Aim: To investigate the neuro-protective effects and underlying mechanisms of uric acid on rat cerebral ischemia/reperfu......
Aim: To investigate the effects of MNG extracted from Cornus officinalis on neurogenesis and Wnt signaling after focal c......
Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and i
Aim: In this study we investigated the neuroprotective effect of oxysophoridine (OSR) on ischemia and ischemia-like insu......
Aim: To study the effect of Garidi-13 on neurological score, pathological changes,serum levels of NSE, TNF-α, IL-1β, I......
Inhibition of autophagy aggratated oxygen-glucose deprivation/reperfusion induced neuron injury in v
Objective Several lines of evidences indicated that autophagy was involved in ischemic brain injury.Ischemia/reperfusion......
Gene expression profiling of microvessels and neurons in brain ischemic penumbra by laser capture mi
Objective Angiogenesis and inflammation are induced immediately after cerebral ischemia,and play a pivotal role in the s......
Neuroprotection of neuroserpin in oxygen-glucose deprivation-and reoxygenation-treated rat neurons a
Neuroserpin (NSP) is regarded for its neuroprotection in cerebral ischemic animal models and patients;our current study ......
Astragalus Membranaceus and Ligustrazine Combination Ameliorates Micro-hemorrhage Through Maintainin
Ethnopharmacological relevance Hemorrhagic transformation is a frequent asymptomatic event that occurs after acute ische......
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both pa
Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporte......
Objective Cerebral ischemia may contribute to the pathogenesis of Alzheimers disease (AD), however, the neuropathologica......
Environmental enrichment preserves cortical inputs to the parahippocampal areas and reduces post str
Objective Reduction in neuronal activity in remote brain regions after stroke is likely caused by a disruption of affere......
Delta-opioid receptor antagonist naltrindole attenuates electroacupuncture neuroprotection in transi
Acupuncture has been widely used to treat stroke in China.However,the possible mechanisms underlying are still unclear.I......
Neuroprotective effects of pioglitazone is associated with PPARγ-mediated inhibition of NF-κB signal
Objective To investigate the neuroprotective actions of pioliotazone (Piog) and the effects of Piog-mediated PPART activ......
The influences of tetramethylpyrazine on region cerebral blood flow temporal cortex after focal cere
Objective Using laser-Doppler flowmetry (LDF),the influence of tetramethylpyrazine (TMP) on regional cerebral blood flow......
Influence of Compatibility of Astragalosides with Panax Notoginseng Saponins on MMP-9 and TIMP-1 aft
Aim: To investigate the effect of compatibility of Astragalosides (AST) with Panax Notoginseng Saponins (PNS) on the exp......
The Protective Effect of the New Compound XJ-1 from Dragon’s Blood on Oxidization Injury of Cerebral
Objective: To investigate the protective effect of the new compound XJ-1 which was derived from Chinese herb Dragon’s b......
HAMI 3379, A CysLT2R Antagonist, Dose-And Time-Dependently Attenuates Brain Injury And Inhibits Micr
Cysteinyl leukotrienes (CysLTs) induce inflammatory responses by activating their receptors,CysLT1R and CysLT2R.We have ......
Neuroprotection of paclitaxel against cerebral ischemia/reperfusion induced brain injury through JNK
In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and the possible......
Molecular mechanism and functional research of GAPDH S-nitrosylation induced by cerebral ischemia-re
Objective Glycer-aldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, has long been considered a housekeepin......
Parkin-dependent mitophagy induced by acidic postconditioning extends reperfusion window in focal ce
Prompt reperfusion after cerebral ischemia is critical for neuronal survival.Any strategies extend the limited reperfusi......
The function of aquaporin 9(AQP9)and its corresponding mechanism in chronic cerebral ischemia are not well defined.We re......
Long-term metformin treatment reduces the risk of stroke.However,the effective administration pattern and indications of......
目的：microglial cells are the innate immune effector cells of the brain,which are the key to the post-traumatic injury an......
Quantitative identification of compounds-dependent on-modules and differential allosteric modules fr
Module-based methods have made much progress in deconstructing biological networks.However, it is a great challenge to q......
Picroside Ⅱ Inhibits Neuronal Apoptosis and Improves the Morphology and Structure of Brain Tissue Fo
This paper aimed to explore the protective effects of picroside Ⅱ against the neuronal apoptosis and changes in morphol......
Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte mig
Currently effective neuroprotective agents are still not availablefor cerebral ischemia, probably due to its complicated......
Therapeutic neuroprotective effects of Ginkgolide B on cortex and basal ganglia in a rat model of tr
Cerebral ischemia and reperfusion is one of the leading causes for death and severe disabilities in the world and often ......
